The Gunners will visit the tricky Norwegian outfit in one of eight early kick-offs while Mourinho's men lock horns with the Copa del Rey holders needing nothing short of a victory.

With Matchday 4 of the UEFA Champions League coming to a wrap, the focus shifts over to the UEFA Europa League, as Europe's second-tier club competition gears up for another exciting round of fixtures.

A total of 16 games will be played, with eight of those fixtures scheduled to kick off at 12:45 p.m. ET. Arsenal are one of the teams taking to the field early as Arteta's high-flying side prepare to face tricky Norwegian outfit Bodø/Glimt.

The Gunners aren't the only Premier League giants to keep an eye on as Manchester United will also be in action while Jose Mourinho's Roma gear up for a tricky showdown as the Italians could be facing demotion to the UEFA Europa Conference League. Here's everything you need to know about the October 13 fixtures in the Europa League.

Top games to watch on Matchday 4 of the UEFA Europa League

Manchester United vs Omonia Nicosia

Manchester United will look to continue their lovely form when they return to action in Europe as Ten Hag's men aim to make it three wins in a row when they host Omonia Nicosia. Rashford and Co. enter this clash on the back of their crucial 2-1 victory over Everton in the Premier League over the weekend, with that result helping the Red Devils climb to fifth in the table. The English giants will also have one eye on their upcoming showdown with Newcastle this weekend and victory on Thursday would be the best way to enter that clash with the Magpies.

Omonia Nicosia, meanwhile, are bottom of the table after losing all of their opening three games. The Cypriot club came close to pulling off an upset against Manchester United last week when they first met, losing 3-2. Neil Lennon's men took a surprise lead against the run of play and while the Red Devils dominated the proceedings and were the deserved winners, the minnows could have stolen a point.

Bodø/Glimt vs Arsenal

One of the eight early kick-offs will see Arsenal take on Bodø/Glimt in what should be an interesting clash. The Gunners beat the Norwegian outfit 3-0 when the pair locked horns last week, with goals from Eddie Nketiah, Rob Holding, and Fabio Vieira securing a second consecutive victory for Arteta's men and maintaining their perfect start in Europe.

However, Bodø/Glimt troubled the North London giants in the second half of that showdown, thus forcing Mikel to bring on Gabriel Jesus, Bukayo Saka, Martin Odegaard, and Ben White to see out that match. The home advantage is no longer in Arsenal's hands, but after back-to-back wins in the Premier League over Tottenham and Liverpool, the Gunners are in no shortage of confidence.

Real Betis vs Roma

Real Betis look to maintain their perfect start in the UEFA Europa League while Roma aim to save their season as Mourinho's men are in danger of crashing out in the group stage. When the pair faced off last week, the Spanish outfit came away from Rome with the three points courtesy of a 2-1 win thanks to goals from Guido Rodriguez and Luiz Henrique, meaning after three games, Pellegrini's men boast nine points.

The Giallorossi, on the other hand, have only three points to their name so far after losing two of their opening three outings. Another defeat could leave Abraham and Co. four points behind the no.2 spot should Ludogorets triumph over HJK, hence the concern. However, after beating Lecce and Inter Milan in their last two Serie A fixtures, Roma should enter this clash with some form.

Who's out for Matchday 4 in the UEFA Europa League?

Real Sociedad: Robin Le Normand, Umar Sadiq, Mikel Oyarzabal, Martin Merquelanz, Ander Barrenetxea, Momo Cho, and Igor Zubeldia (all injured)

Freiburg: Rolland Sallai and Kimberly Ezekwem (injured)

Nantes: Fabien Centonze (injured)

Manchester United: Donny van de Beek, Martin Dubravka, Aaron Wan-Bissaka, Anthony Martial, and Harry Maguire (all injured)

Roma: Georginio Wijnaldum, Rick Karsdorp, Ebrima Darboe, Paulo Dybala, and Zeki Celik (injured); Nicolo Zaniolo (suspended)

Lazio: Marco Bertini and Mohamed Fares (injured)

Feyenoord: Oussama Idrissi (injured)

Monaco: Ruben Aguilar (injured)

Real Betis: Juanmi (injured); Martin Montoya and Loren Moron (ineligible)

Arsenal: Mohamed Elneny, Emile Smith Rowe, and Oleksandr Zinchenko (injured)

Bodø/Glimt: Sondre Fet (injured)

PSV: Noni Madueke (injured); Olivier Boscagli, Mauro Junior, Luuk de Jong, and Marco van Ginkel (doubtful)

Full list of games for Matchday 4 in the UEFA Europa League