El Trafico, Portland Timbers vs Seattle Sounders, Inter Miami vs Atlanta United and more to kick off MLS MD 4

Topics: TV SCHEDULES, MLS, INTER MIAMI, LA GALAXY, LA FC, PHILADELPHIA UNION, AUSTIN FC, COLUMBUS CREW SC, ATLANTA UNITED, TORONTO FC, NYC FC, NEW YORK RED BULLS

Portland Timbers vs Seattle Sounders and El Trafico are among the biggest games taking place during matchday four, which starts on Friday, May 7th and ends on Sunday, May 9th.

Matchday four is set to get underway on Friday, May 7th and there are plenty of big matches in store for fans. Let's have a look at what's in store over the next few days.

Key headlines - MLS matchday four

Former Manchester United teammates set to go head to head as Inter Miami and Atlanta United lock horns

On Sunday, Inter Miami will welcome Atlanta United. Both teams have picked up four points from their first three games, with one win, one loss, and one draw to date. This game will be really interesting as it will pit former Manchester United teammates Phil Neville and Gabriel Heinze against each other. The two men were colleagues at Old Trafford for one season, during the 2004/2005 season, and for the first time, the two former defenders will face off on opposite ends of the pitch.

Carlos Vela to miss El Trafico?

LA Galaxy could be dealt a huge blow with star man Carlos Vela in major doubt for the upcoming El Trafico derby this weekend. Head coach Bob Bradley hasn't confirmed if he'll be fit in time for Saturday's clash but fans will be really looking forward to see him and Chicharito line up on opposite sides of the pitch. Just one point divides the two teams heading into the derby meeting.

Higuain brothers set to miss upcoming Inter Miami game due to mother's passing

Both Gonzalo and Federico Higuain are still on personal leave following their mother's recent passing due to illness and so will not be featuring in Sunday's game against Atlanta United. This will mean that coach Phil Neville will have to look to other options up front for his crunch match when Atlanta come to town.