League leaders Bayer Leverkusen's bid for a debut Bundesliga title is likely to hinge on how well Xabi Alonso's side account for their Africa Cup of Nations absences.
Unbeaten Leverkusen sit four clear of second-placed Bayern, who have a game in hand, but need to do without the AFCON-bound Odilon Kossounou, Edmond Tapsoba and Amine Adli.
A fourth, Nigeria striker Victor Boniface, was set to make his AFCON debut but injured his groin in training and will be out until April after undergoing surgery.
The tournament starts on Saturday and runs until February 11.
That period includes crucial league fixtures at home to Bayern and away at fourth-placed RB Leipzig, as well as a German Cup quarter final with in-form Stuttgart.
Alonso's side have won 22 and drawn three of 25 games this season, thanks in large part to their African contingent.
Boniface has been the standout since arriving in the summer, scoring 10 and assisting seven more in the league.
Czech striker Patrik Schick has made a timely return from injury and will need to step up in the Nigerian's absence.
His six goals in nine games in all competitions, at a rate of one goal per 40 minutes including a last-start hat-trick in a 4-0 win over Bochum, will give Leverkusen fans hope.
AFCON will not just impact Leverkusen up front however.
Alonso's side have conceded a league-low 12 goals from 14 matches this season, with centre-backs Kossounou and Tapsoba forming a stable partnership alongside Germany international Jonathan Tah.
Tapsoba, who will represent Burkina Faso, told a group of journalists including AFP in December Leverkusen had enough depth to navigate the difficult period.
"We trust our teammates and everyone's working hard"
"You can see the coach is trying to mix the line-up every game and I think everybody's going to take his chance.
"So we wont worry so much about that."
Alonso shared the sentiment, saying in December "we are losing some players but we have seen that all our players can play."
"I'm not crying and I'm not a victim. We have enough players."
Leverkusen sporting director Simon Rolfes said last month AFCON should be moved, saying it has an impact on whether clubs sign African players.
"For sure all European clubs need to have this in mind" Rolfes said.
"You cannot have 15 African players in your squad and then in January you don't have any players anymore.
"We would like to have the Africa Cup in the summer break between the seasons, but it is what it is."
One to watch: Jadon Sancho (Borussia Dortmund)
Jadon Sancho returned to Borussia Dortmund on loan until the end of the season on Thursday, hoping the familiar surroundings of the club where he made his name will reinvigorate his career.
Sancho scored 50 and made 64 assists in 137 games for Dortmund before a big-money move to Manchester United in 2021.
Sancho has had an unhappy time at United, scoring 12 times in 82 games before falling out with manager Erik Ten Hag.
Fifth-placed Dortmund have also pinned their hopes on the winger.
One of Sancho's last matches in a Dortmund shirt was the 4-1 2021 German Cup victory over RB Leipzig, where he scored twice and laid on another for Erling Haaland.
"Great memories" Sancho told Dortmund's in-house media on Thursday.
"Start winning games, start scoring goals, start assisting... (I) can't wait to get started."
Key stats
Six: Dortmund are six points off fourth place. The last time Dortmund finished outside the top four was in 2014-15, Jurgen Klopp's last year at the club.
Six: Leverkusen have dropped just six of a possible 48 points this campaign. Every team to have scored 40 or more points at this stage of the season have won the title.
Six: Six sides -- Wolfsburg, Bochum, Union Berlin, Mainz, Cologne and Darmstadt -- have scored fewer than Harry Kane's 21 goals this season.
Fixtures (1430 GMT unless stated)
Friday
Bayern Munich v Hoffenheim (1930)
Saturday
Freiburg v Union Berlin, Mainz v Wolfsburg, Augsburg v Bayer Leverkusen, RB Leipzig v Eintracht Frankfurt, Cologne v Heidenheim, Darmstadt v Borussia Dortmund (1730)
Sunday
Bochum v Werder Bremen, Borussia Moenchengladbach v Stuttgart (1630)
