Tottenham Hotspur will be looking for their fifth straight win when they travel to face in-form Newcastle United.
Newcastle are unbeaten so far this season, and have the best defensive record in the Premier League.
Arsenal and Sunderland will both be looking to improve poor starts to the season when they go head to head at the Emirates Stadium.
Arsenal have won only twice in their first seven games, while Sunderland have tasted victory only once this season.
West Bromwich Albion and Wolverhampton Wanderers will clash in the Black Country derby with both teams looking to end poor runs of form.
West Brom are winless in their last three games, while Wolves are looking to avoid suffering their fifth straight defeat.
Bitter rivals Manchester United and Liverpool will go head to head at Anfield in Saturday’s early kickoff.
Manchester United manager Sir Alex Ferguson had added to the pre-game hype by describing this clash as “the game of the season in English Football.”
Liverpool captain Steven Gerrard is expected to make his first start of the season, while England defender Glen Johnson could also return for the Reds. Martin Kelly, Daniel Agger and Fabio Aurelio are also available for Liverpool.
United captain Nemanja Vidic is struggling with a calf strain and will be assessed ahead of kickoff. Tom Cleverley and Rafael Da Silva are ruled out with injury for the Red Devils, while Chris Smalling is a question mark.
Stoke City will be looking to continue their unbeaten home record when they play host to Fulham.
Fulham have not yet won away from home this season, but will have had their confidence boosted by the 6-0 win over Queens Park Rangers last time out.
Stoke midfielder Glenn Whelan may be rested after midweek international duty, while Matthew Etherington is struggling with a back injury. Kenwyne Jones, Jermaine Pennant and Marc Wilson are also injury doubts for Stoke.
Philippe Senderos, Kerim Frei and Bryn Ruiz are all sidelined for Fulham, while Aaron Hughes will return from a groin injury.
Queens Park Rangers will play host to Blackburn Rovers with both teams looking to boost morale with a win.
QPR will be hoping to rebound from a 6-0 drubbing at Fulham last time out, while Blackburn will want to avoid sliding to a third straight defeat.
Matt Connolly is an injury doubt for QPR, while fellow defender Danny Gabbidon is sidelined with a knee problem.
Defender Michel Salgado and midfielder David Dunn are both expected to return from injury for Blackburn.
Wigan Athletic and Bolton Wanderers will go head to head on Saturday with both teams looking to end miserable runs of form.
Bolton are bottom of the table after six straight defeats, while Wigan are also in the bottom three and have lost four matches.
Hugo Rodallega is an injury absentee for Wigan, while James McCarthy is doubtful with illness. Steve Gohouri and Albert Crusat will return for Wigan from suspension and injury respectively.
Bolton will be boosted by the return to the lineup of Jussi Jaaskelainen and Gael Kakuta, while David Wheater and Ivan Klasnic are back from suspension.
Norwich City and Swansea City will meet in a battle of newly promoted teams at Carrow Road.
Both teams have started the season well, and sit 8th and 9th in the league table respectively.
Striker Steve Morison is fit to play for Norwich, while Andrew Crofts should be healthy despite picking up a knock while playing for Wales in midweek.
Leon Britton had recovered from injury for Swansea, while Garry Monk and Ashley Williams are the only fit center backs for the Swans.
Manchester City will play host to Aston Villa will both teams looking to keep their unbeaten Premier League records intact.
City are currently behind league leading Manchester United on goal difference alone, while Villa currently sit in 7th place.
Leading goal scorer Sergio Aguero is ruled out with injury for City, while Mario Balotelli will overcome a back injury in time to play.
Midfielder Owen Hargreaves could make his league debut for City, as manager Roberto Mancini is expected to rotate his squad after so many players saw international action in midweek.
Stephen Ireland, Barry Bannan and James Collins are expected to be fit for Villa, while leading goal scorer Gabriel Agbonlahor has shaken off a back injury in time to play.
Villa goalkeeper Shay Given and defender Richard Dunne will be facing their former club.
Chelsea will be looking for their third straight win when they play host to Everton in Saturday’s late kickoff.
Third placed Chelsea are only three points behind league leading Manchester United. Everton are only two points above the bottom three after losing their last two games.
David Luiz could be rested by Chelsea after playing for Brazil twice in midweek, while Fernando Torres is suspended.
Tim Cahill and John Heitinga are injury doubts for Everton and wil be assessed ahead of kickoff.
West Bromwich Albion and Wolverhampton Wanderers will clash in the Black Country derby with both teams looking to end poor runs of form.
West Brom are winless in their last three games, while Wolves are looking to avoid suffering their fifth straight defeat.
Peter Odemwingie and Steven Reid are injury doubts for West Brom and will be assessed ahead of kickoff.
Leading goal scorer Steven Fletcher is out injured for Wolves along with George Elokobi, Ronald Zubar could make his long awaited return from injury.
Arsenal and Sunderland will both be looking to improve poor starts to the season when they go head to head at the Emirates Stadium.
Arsenal have won only twice in their first seven games, while Sunderland have tasted victory only once this season.
Bacary Sagna is ruled out for Arsenal, while the Gunners will be boosted by the return from injury of Tomas Rosicky, Johan Djourou and Laurent Koscielny.
Phil Bardsley is suspended for Sunderland, while on-loan striker Nicklas Bendtner is ineligible to play against his parent club. Attacking midfielder Seb Larsson is fit for Sunderland and will relish the prospect of playing against his former employers.
Tottenham Hotspur will be looking for their fifth straight win when they travel to face in-form Newcastle United.
Newcastle are unbeaten so far this season, and have the best defensive record in the Premier League.
Danny Guthrie and Sammy Ameobi are injury doubts for Newcastle, while Yohan Cabaye and Demba Ba are fit to play for the Toon Army. In-form striker Ba has scored four goals in his last two Premier League games.
Vedran Corluka and Niko Kranjcar are ruled out for Tottenham, while Emmanuel Adebayor, Aaron Lennon and Sandro are injury doubts.
Arsenal and Sunderland will both be looking to improve poor starts to the season when they go head to head at the Emirates Stadium.
Arsenal have won only twice in their first seven games, while Sunderland have tasted victory only once this season.
West Bromwich Albion and Wolverhampton Wanderers will clash in the Black Country derby with both teams looking to end poor runs of form.
West Brom are winless in their last three games, while Wolves are looking to avoid suffering their fifth straight defeat.
Bitter rivals Manchester United and Liverpool will go head to head at Anfield in Saturday’s early kickoff.
Manchester United manager Sir Alex Ferguson had added to the pre-game hype by describing this clash as “the game of the season in English Football.”
Liverpool captain Steven Gerrard is expected to make his first start of the season, while England defender Glen Johnson could also return for the Reds. Martin Kelly, Daniel Agger and Fabio Aurelio are also available for Liverpool.
United captain Nemanja Vidic is struggling with a calf strain and will be assessed ahead of kickoff. Tom Cleverley and Rafael Da Silva are ruled out with injury for the Red Devils, while Chris Smalling is a question mark.
Stoke City will be looking to continue their unbeaten home record when they play host to Fulham.
Fulham have not yet won away from home this season, but will have had their confidence boosted by the 6-0 win over Queens Park Rangers last time out.
Stoke midfielder Glenn Whelan may be rested after midweek international duty, while Matthew Etherington is struggling with a back injury. Kenwyne Jones, Jermaine Pennant and Marc Wilson are also injury doubts for Stoke.
Philippe Senderos, Kerim Frei and Bryn Ruiz are all sidelined for Fulham, while Aaron Hughes will return from a groin injury.
Queens Park Rangers will play host to Blackburn Rovers with both teams looking to boost morale with a win.
QPR will be hoping to rebound from a 6-0 drubbing at Fulham last time out, while Blackburn will want to avoid sliding to a third straight defeat.
Matt Connolly is an injury doubt for QPR, while fellow defender Danny Gabbidon is sidelined with a knee problem.
Defender Michel Salgado and midfielder David Dunn are both expected to return from injury for Blackburn.
Wigan Athletic and Bolton Wanderers will go head to head on Saturday with both teams looking to end miserable runs of form.
Bolton are bottom of the table after six straight defeats, while Wigan are also in the bottom three and have lost four matches.
Hugo Rodallega is an injury absentee for Wigan, while James McCarthy is doubtful with illness. Steve Gohouri and Albert Crusat will return for Wigan from suspension and injury respectively.
Bolton will be boosted by the return to the lineup of Jussi Jaaskelainen and Gael Kakuta, while David Wheater and Ivan Klasnic are back from suspension.
Norwich City and Swansea City will meet in a battle of newly promoted teams at Carrow Road.
Both teams have started the season well, and sit 8th and 9th in the league table respectively.
Striker Steve Morison is fit to play for Norwich, while Andrew Crofts should be healthy despite picking up a knock while playing for Wales in midweek.
Leon Britton had recovered from injury for Swansea, while Garry Monk and Ashley Williams are the only fit center backs for the Swans.
Manchester City will play host to Aston Villa will both teams looking to keep their unbeaten Premier League records intact.
City are currently behind league leading Manchester United on goal difference alone, while Villa currently sit in 7th place.
Leading goal scorer Sergio Aguero is ruled out with injury for City, while Mario Balotelli will overcome a back injury in time to play.
Midfielder Owen Hargreaves could make his league debut for City, as manager Roberto Mancini is expected to rotate his squad after so many players saw international action in midweek.
Stephen Ireland, Barry Bannan and James Collins are expected to be fit for Villa, while leading goal scorer Gabriel Agbonlahor has shaken off a back injury in time to play.
Villa goalkeeper Shay Given and defender Richard Dunne will be facing their former club.
Chelsea will be looking for their third straight win when they play host to Everton in Saturday’s late kickoff.
Third placed Chelsea are only three points behind league leading Manchester United. Everton are only two points above the bottom three after losing their last two games.
David Luiz could be rested by Chelsea after playing for Brazil twice in midweek, while Fernando Torres is suspended.
Tim Cahill and John Heitinga are injury doubts for Everton and wil be assessed ahead of kickoff.
West Bromwich Albion and Wolverhampton Wanderers will clash in the Black Country derby with both teams looking to end poor runs of form.
West Brom are winless in their last three games, while Wolves are looking to avoid suffering their fifth straight defeat.
Peter Odemwingie and Steven Reid are injury doubts for West Brom and will be assessed ahead of kickoff.
Leading goal scorer Steven Fletcher is out injured for Wolves along with George Elokobi, Ronald Zubar could make his long awaited return from injury.
Arsenal and Sunderland will both be looking to improve poor starts to the season when they go head to head at the Emirates Stadium.
Arsenal have won only twice in their first seven games, while Sunderland have tasted victory only once this season.
Bacary Sagna is ruled out for Arsenal, while the Gunners will be boosted by the return from injury of Tomas Rosicky, Johan Djourou and Laurent Koscielny.
Phil Bardsley is suspended for Sunderland, while on-loan striker Nicklas Bendtner is ineligible to play against his parent club. Attacking midfielder Seb Larsson is fit for Sunderland and will relish the prospect of playing against his former employers.
Tottenham Hotspur will be looking for their fifth straight win when they travel to face in-form Newcastle United.
Newcastle are unbeaten so far this season, and have the best defensive record in the Premier League.
Danny Guthrie and Sammy Ameobi are injury doubts for Newcastle, while Yohan Cabaye and Demba Ba are fit to play for the Toon Army. In-form striker Ba has scored four goals in his last two Premier League games.
Vedran Corluka and Niko Kranjcar are ruled out for Tottenham, while Emmanuel Adebayor, Aaron Lennon and Sandro are injury doubts.
