Del Bosque's men are surprisingly not top of the table in Group C, with the position currently occupied by Slovakia who beat Spain 2-1 when the two sides met in September last year. The reigning European champions will be adamant to avoid a further blip for it may allow the group leaders to further extend their lead who face an easy fixture against Macedonia.
Barcelona defender Gerard Pique was jeered by his own fans after making controversial remarks but has insisted that he will not let that effect his performance.
"The thing is that I have just come from winning the treble," Pique explained.
"I'm very, very happy. Smile from ear to ear. And that is the perfect reply to the shouts - a smile."
"Don't think that the shouts affect me. It is part of my job. I don't think it's unjust. The people are welcome to protest, it's their right to do it."
Meanwhile Spain head coach Vicente Del Bosque has called for unity ahead of the important match against Belarus and has appealed for the supporters to stand behind all the players.
"I don’t think what happened is right," Del Bosque said. "Whistling one player is the same as whistling the whole team.
"It leaves me with a very bad taste. The most important thing is that we are united."
Pique's club teammate Marc Bartra also condemned the reactions of a certain section of fans towards the former Man United man and has insisted that he deserves a better treatment.
"He doesn't deserve that," Bartra told reporters.
"In footballing terms he has always gone to the ends of the earth for Barcelona and the national side. It makes me sad because he's a good guy.
"Maybe he lost his head a bit but in the end people have to remember everything he has given."
Spain have not been on their best runs in recent games having suffered two defeats in their last five matches which includes losses at the hands of Netherlands and Germany. It is important that the 2010 World Champions produce a better performance this time around especially because third placed Ukraine trail them by just three points.
Spain emerged successful when the two sides met in the reverse fixture back in November. Isco opened up the scoring for the home side in the match followed by goals from Busquets and Pedro to hand Spain a comfortable 3-0 win.
Belarus on the other hand have managed just four points from the five matches they have played but manager Aleksandr Khatskevich is confident that his team can get a positive result.
"I will accept any result as long as there are no half-hearted players in the team.
"Of course Spain are better than us in every aspect but we can fight them with our team game and try to exploit their weaknesses. And they have those weaknesses, trust me."
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