Los Colchoneros won't have Diego Godin and Tiago available for the second leg, which will force Simeone to improvise in defense.

With a lonely goal by Hakan Calhanoglu, Bayer Leverkusen will travel to Madrid with a narrow lead to face Atletico at Vicente Calderon stadium. Despite not having to overcome a huge deficit, things may not be as easy for Simeone's men, since they won't be able to start neither Diego Godin nor Tiago. Godín saw his third yellow card of the tournament after a hard tackle on Lars Bender, while Tiago was booked twice before being sent off. Atletico's Number 5 became the first player in club history to be sent off during a Champions League match.

Things were going the right way for Atletico during the first 45 minutes, but coach Simeone was forced to change his tactics after injuries to Siqueira and Saul Ñiguez. After the break, Calhanoglu scored thanks to a backheel assist by Bellarabi, making Leverkusen's fans crazy.

Simeone used his last substitution by giving way to Fernando Torres, but El Niño was not able to make a difference for Atletico, and now last year's runner-up will have to find their top game to eliminate a complicated German side.

Fans reacted to Calhanoglu's goal, as well as Atletico's chances for the upcoming match. Want to know what they think? Scroll down and find out!

"Schmidt vs Mono Burgos and Simeone"

"Every great thing Simeone has as a coach goes down the drain with his poor attitude when he loses. He is a poor loser."