Plenty of big fixtures to look forward to as the Premier League resumes action, on Saturday, September 11th, with Manchester United-Newcastle being one of the ones not to miss.

The international break is finally over, meaning that fans will be able to get back to watching their favorite players in action for their respective clubs. Matchday four of the 2021/22 Premier League season will get underway on Saturday, September 11th, and there is already quite a bit of buzz about whether Cristiano Ronaldo will make an appearance in his highly-awaited return to Old Trafford this weekend.

Here's all you need to know ahead of matchday four.

Premier League standings heading into matchday four

So far, only Tottenham continues to have a perfect 100 per cent record after three rounds, thus giving Spurs a slight advantage over the chasing pack. Will we see some shake-ups in the top five by the time matchday four finishes on Monday?

Premier League games you won't want to miss on matchday four

Crystal Palace vs Tottenham: Nuno's squad are still the only team yet to drop points and Spurs will be looking to take advantage of Crystal Palace's poor start by nicking all three points in another London derby. However, they'll be worried about the availability of Son Heung-min, who picked up an injury while on international duty for South Korea.

Leicester City vs Manchester City: Both Leicester and Manchester City come into this match tied on points - six each - but it's the Cityzens who sit ahead thanks to their vastly superior goal difference. To date, Pep Guardiola's men have scored a whopping ten goals in just their first three games, while conceding just once. Meanwhile, the Foxes certainly haven't been slouches, but that formidable form will be certainly something they'll be wary of as they look to avoid being put to the sword.

Manchester United vs Newcastle United: Quite a few more eyes will be eagerly following this match, especially as there have been growing reports that Cristiano Ronaldo could be making his long awaited second debut. Even better, the game will be at Old Trafford, the place he made a name for himself on the global stage. Now in his second spell, will this game see him have an impact in front of the home crowd?

Chelsea vs Aston Villa: This match could see the debut of Saul, who was signed on deadline day to help bolster the Champions League winners as they look to compete on multiple fronts this season. Aston Villa, by contrast, won't be able to feature their new big-money signing Emiliano Buendia after the whole drama surrounding his trip to Brazil with the Argentinian national team. 

Leeds United vs Liverpool: The Reds will be in action against Leeds United to wrap up matchday four on Monday. It hasn't been the best start to the season for Leeds, who are still seeking their first win after picking up just two points from their first three games.

Team news for matchday four

Here's who's out or in doubt for matchday four:

All info current as of 09 September 2021

Manchester City: Gabriel Jesus (COVID-19 regulations), Ederson (COVID-19 regulations), Phil Foden (Ankle Injury), Kevin De Bruyne (Ankle Injury), Zack Steffen (COVID-19), Aymeric Laporte (Other Issue), Benjamin Mendy (Suspended by club)

Manchester United: Marcus Rashford (Shoulder Injury), Phil Jones (Knee Injury), Scott McTominay (Groin/Hip Injury), Alex Telles (Ankle/Foot Injury), Fred (unavailable due to FIFA COVID-19 protocols), Jadon Sancho (in doubt but expected to recover in time for game), Dean Henderson (other issue)

Liverpool: Alisson Becker (FIFA COVID-19 regulations), James Milner (In doubt due to calf injury, but could make bench for upcoming match), Roberto Firmino (Thigh Injury), Takumi Minamino (Thigh Injury), Neco Williams (Ankle Injury), Fabio Tavares (FIFA COVID-19 regulations)

Chelsea: Reece James (Suspended), N'Golo Kante (In doubt due to ankle/foot injury), Thiago Silva (COVID-19 quarantine regulations), Christian Pulisic (In doubt due to ankle/foot injury), Romelu Lukaku (May be in doubt due to thigh injury)

Tottenham: Cristian Romero (COVID-19 quarantine regulations), Giovani Lo Celso (COVID-19 quarantine regulations), Davinson Sanchez (COVID-19 quarantine regulations), Steven Bergwijn (Ankle/Foot Injury), Son Heung-Min (Calf Injury), Ryan Sessegnon (Knock), Tanguy Ndombele (Other issue)

Arsenal: Mohamed Elneny (Thigh Injury), Granit Xhaka (Other issue), Takehiro Tomiyasu (In doubt due to work permit and match fitness), Thomas Partey (In doubt due to ankle injury, but looks likely to return), Edward Nketiah (In doubt due to ankle injury, could make bench), Sead Kolasinac (In doubt, will need to pass late fitness test), Emile Smith Rowe (In doubt due to illness), Nicolas Pepe (Illness)

Premier League matchday four fixtures