Elsewhere, Man City will travel to Everton while RB Leipzig and Schalke will lock horns in a clash between first and fifth in the league. Check out our list of must-watch games.

What to watch on Saturday, September 28, 2019

Everton vs Man City at 12:30 ET/16:30 GMT

Broadcast listings: Telemundo Deportes En Vivo, NBCSports.com, NBC Sports App, UNIVERSO NOW, UNIVERSO, NBC, SiriusXM FC in the USA; BBC Radio Manchester, SKY GO Extra, Sky Sports Main Event, Sky Sports Premier League in the UK; DAZN in Canada; Optus Sport in Australia

Preview: The defending champions will be in action on Saturday and will be aiming for another impressive win after their 8-0 triumph over Watford. Everton, meanwhile, are on a two-game losing streak in the league and will be keen on ending this run when the Citizens arrive. 

Getafe vs Barcelona at 10:00 ET/14:00 GMT

Broadcast listings: beIN SPORTS, Fanatiz USA, beIN SPORTS CONNECT, beIN SPORTS en Español in the USA; Premier Player HD in the UK; beIN SPORTS en Español, beIN SPORTS CONNECT Canada, beIN Sports Canada in Canada; beIN SPORTS 2, beIN Sports Connect, Kayo Sports in Australia; Mitele Plus, Movistar+, Movistar Laliga in Spain

Preview: Barcelona did win their last game, beating Villarreal 2-1 at Camp Nou, but the Blaugrana remain a shadow of their former selves. Defensive frailties are made worse but the fitness struggles of Lionel Messi, the man who always papered over the cracks for the Blaugrana.

Messi to spend a few more days on the sidelines

Lionel Messi, Barcelona, Villarreal, La Liga

He made his first start in the midweek clash but came off at half-time after picking up a groin injury. He is expected to be back quickly but this clash with Getafe comes too soon. Valverde's men haven't won an away game this season. Will they grab their first victory on Saturday? Tune in to find out.

Atletico vs Real Madrid at 15:00 ET/19:00 GMT

Broadcast listings: beIN SPORTS, beIN SPORTS en Español, Fanatiz USA, beIN SPORTS CONNECT in the USA; Premier Player HD, Premier Sports 1 in the UK; beIN SPORTS en Español, beIN Sports Canada, beIN SPORTS CONNECT Canada in Canada; beIN Sports Connect, beIN Sports 1, Kayo Sports in Australia; Partidazo in Movistar LaLiga, Mitele Plus, Movistar Laliga, Movistar+ in Spain

Preview: The Madrid Derby! First and second in the league will lock horns in what is always a feisty encounter. Despite their poor start to the season, Real Madrid find themselves on top in the standings, a point ahead of second-placed Atletico, and could widen the gap with a win at the Wanda Metropolitano Stadium.

First vs second in the Madrid Derby

Atletico Madrid, Real Madrid, Madrid Derby, La Liga

The last time these two clubs met was in the International Champions Cup it what was meant to be a friendly. Simeone's men won 7-3 in a game that saw Diego Costa and Dani Carvajal get sent off. Los Rojiblancos will have to make do in this showdown without Alvaro Morata who was sent off in Atletico's most recent game while Modric is tipped to make his return this weekend. Don't miss this showdown.

RB Leipzig vs Schalke 04 09:30 ET/13:30 ET

Broadcast listings: FOX Soccer Match Pass, Foxsports.com, Fox Sports 2, FOX Deportes in the USA; 

Sportsnet Now, Sportsnet World Now in Canada; beIN Sports Connect, Kayo Sports in Australia; Sky Go, Sky Sport Bundesliga 1, Sky Sport Bundesliga 3 in Germany

Preview: RB Leipzig's unbeaten form in the league will be tested once more this Saturday when they host fifth-placed Schalke. A 1-1 draw with the Bayern Munich was the only time the league leaders have dropped points this season. Will they bag three points? Tune in to find out.

Juventus vs SPAL at 09:00 ET/13:00 GMT

Broadcast listings: ESPN+ in the USA; TLN, DAZN in Canada; Kayo Sports, beIN Sports Connect, beIN Sports 1 in Australia; NOW TV, SKY Go Italia, Sky Calcio 1, Sky Supercalcio HD, Sky Sport Serie A in Italy

Preview: Juventus are yet to hit their best this season. Since throwing away a 2-0 lead to draw 2-2 against Atletico Madrid in the Champions League, the Old Lady have won back-to-back games in Serie A but both were 2-1 triumphs in which the reigning champions were tested. Next up are SPAL, who sit second from last in the standings.

What to watch on Sunday, September 29, 2019

Milan vs Fiorentina 14:45 ET/18:45 GMT

Broadcast listings: ESPN+, Rai Italia America in the USA; Premier Player HD, Premier Sports 2 in the UK; TLN, Rai Italia America, DAZN in Canada; Rai Italia Australia, beIN Sports 1, beIN Sports Connect, Kayo Sports in Australia; NOW TV, SKY Go Italia, Sky Calcio 1, Sky Sport Serie A, Sky Sport Uno, Sky Supercalcio HD in Italy

Preview: AC Milan head into this game on the back of their recent Milan Derby defeat to Inter. They lost that game 2-0 and thus dropped down to 10th. Fiorentina, meanwhile, sit five spots beneath them in 15th and will want to beat the Italian giants.

What to watch on Monday, September 30, 2019

Man United vs Arsenal at 15:00 ET/19:00 GMT

Broadcast listings: NBC Sports App, SiriusXM FC, Telemundo Deportes En Vivo, UNIVERSO NOW, NBCSN, UNIVERSO in the USA; Sky Sports Premier League, Sky Sports Main Event, SKY GO Extra in the UK; DAZN in Canada; Optus Sport in Australia

Preview: This is the Premier League clash everyone is waiting for. Man United and Arsenal, England's two most feared sides in the early 2000s, will face off at a time when questions are being asked of their capabilities.

Both sides enjoyed Carabao Cup victories over the midweek, the Gunners triumphing 5-0 while the Red Devils required a penalty shootout. However, in the Premier League, both sides have shown cracks, with Solskjaer's men losing 2-0 at West Ham and Emery's side nearly dropping points at home to Aston Villa after another abysmal defensive display.

Fortunately, both sides will welcome back key names for this tie. For the home side, Paul Pogba is expected to return to the starting lineup after being sidelined for the past few games. Arsenal, meanwhile, saw Bellerin and Holding return to the first team for the first time in a long time while Tiernay made his debut and impressed. 

With Holding, Bellerin, and Tierney back, could this be Arsenal's new back-four?

Rob Holding, Hector Bellerin, Keiran Tierney, Calum Chambers, Arsenal