And the two Spurs stars appear destined to miss the club's Champions League opener against Inter Milan.

The international break has a tendency to hand clubs injury setbacks, and that is the case for Tottenham this time around. The north London outfit has been handed a huge blow ahead of their crucial clash with Liverpool this weekend.

With the Premier League returning to action this Saturday, Spurs will be without one key player when they host Klopp's men in the early kick-off. That man is none other than Dele Alli.

The Englishman picked up an unfortunate knock in the UEFA Nations League defeat to Spain. As a result, Pochettino could be without the Three Lions ace for more than one crucial tie.

Speaking ahead of Saturday's high-stakes encounter, the Argentine tactician revealed that the Liverpool clash isn't the only game he could be forced to sit out. The Tottenham boss told Sky Sports:

"Alli is a bit unlucky, he suffered a small injury after 20 minutes against Spain.

"Disappointed, because we're going to miss him for this game, and possibly Inter Milan in the Champions League, but it is not a big issue."

To make things worse, Alli isn't the only Tottenham star set for a spell on the sidelines. That man is Hugo Lloris, with Pochettino confirming that the club captain could spend several weeks on the sidelines due to his thigh injury.

While the Liverpool clash is a big game, their Champions League opener against Inter Milan is the crucial one. The London giant drew not only the Serie A outfit but also Barcelona and PSV in the group stage. In this group of death, every single point counts, and this double injury blow hurts Tottenham's chances of enjoying a perfect start in Europe.