Three years after accusing him of racial abuse, Seydou Keita throws a bottle at Pepe during their respective sides' ICC clash

Football fans in the US, as the rest of the world, attending a friendly game witnessed a heated exchange when La Liga giants Real Madrid took on Serie A side AS Roma in the International Champions Cup.

Two of the respective sides' players got into a confrontation, Mali midfielder Seydou Keita and Portugal center-back Pepe.

Keita, a former Barcelona player, refused to shake the hands of Los Blanco defender, before throwing a water bottle at the Real Madrid player afterwards.

The Roma midfielder, who signed for Rudi Garcia's side from Valencia this summer, had previously got into a controversial spat with Pepe when his ex-club the Blaugrana went head-to-head with Les Merengues in El Clasico, back in 2011.

Seydou Keita accused Pepe of calling him a monkey, an incident which presumably caused the two players to lock horns once again, three years later.

VIDEO: Seydou Keita refuses to shake hands with Pepe, then throws a water bottle at the Real defender

Other players had to step in to separate the two during the pre-match pomp, an altercation which was further aggravated when, according to Fox (per 101 Great Goals), the 31-year-old Real Madrid center-back spat on the Giallorossi midfielder.

"Keita accused Pepe of calling him a monkey during the first leg of the Spanish Supercopa in 2011. According to the Fox broadcast for the Roma-Real Madrid match, the fourth official said that Pepe spat at Keita at some point during the handshake/water bottle incident, as well," later revealed Dirty Tackle of Yahoo! Sports.

Players stepping in to cool down the situation between Keita and Pepe

International Champions Cup, Real Madrid, Roma, Pepe, Sergio Ramos, Iker Casillas, Seydou Keita