When both these sides took the field in their opening match of the group stage, Mexico undoubtedly had a hand full of question marks surrounding their manager. After losing that match 2-1, angry Mexican fans expressed their concern surrounding Manuel de la Torre's job security.
Fortunately for de la Torre, El Tri has managed to bounce back, outscoring their opponents 6-1. When you put that stat along side Panama's unbeaten run, having outscored their opponents 9-2, this should be a match with a few goals to offer.
Panama's Gabriel Torres grabbed both goals in their first meeting on July 7th, and he will once again look to be Los Canaleros main offensive threat.
Another headache for Mexico in their opening match was Alberto Quintero, who left Mexico's Israel Jimenez questioning his own footballing abilities. The Panamanian did as he pleased, having taken part in both of Panama's goals.
Since that nightmare, de la Torre has resorted to a replacement for Jimenez at right back, that being Club America's Miguel Layun.
That change may not have helped El Tri play attractive football, or even consistent football for that matter, but it at least has helped them have a chance at a possible Gold Cup Final.
Being at their best will be a must if the Mexicans are to defeat Panama. In order to do that, they will not only need their defenders to be exceptional, but they will also need to get more out of their midfielders, after a boring performance against Trinidad & Tobago.
A victory Wednesday night in Arlington, Texas will see Mexico reach the Gold Cup Final once again, setting up a possible chance of a third consecutive title in this competition.
Watch Panama Vs Mexico Live:
In the UK at 03:00 BST (July 25) on: ESPN UK / HD
Please visit the match page to access our worldwide TV listings. You can get live scores of this Gold Cup quarter-final match available on the home page as soon as the match kicks off.