However, new Sky Blues' boss has played down the tension and rivalry between himself and the Portuguese manager.
Speaking at the pre-match press conference, the 45-year-old coach shared his opinions ahead of the long-awaited reunion with the former Real Madrid chief.
"We are educated people, of course I will shake his hand. Why shouldn't I? We are polite guys. I want to win. So does he.
"It's a friendly, just a friendly."
Guardiola also had words of praise for the Red Devils, telling reporters:
"I believe that with this coach (Mourinho) and good players, they will be a good team."I'm sure they will be stronger than last season."
This will be the first Manchester derby in history to be played outside of England.